There are now over 6000 Positive Clinical Studies and Research Papers that support Photobiomodulation Therapy (PBMT) / Cold Laser Therapy (CLT) / Low-Level Laser Therapy (LLLT) as an effective modality for a wide range of conditions. Over 200,000 health care providers are using cold lasers devices in their practice and over 800,000 individuals have purchased a cold laser for private use. With the growing awareness of prescription drugs many people are turning to high quality therapeutic cold laser devices for effective for pain relief, inflammation reduction, microcirculation increase, and overall healing acceleration.
*While many of the following clinical studies have shown positive results, no medical claims are being made other than for those issued for pain and inflammation on a specific lasers that have been cleared for such by the FDA.
Controlled Double Blind Studies with Photobiomodulation Therapy (PBMT) / Cold Laser Therapy (CLT) / Low Level Laser Therapy (LLLT)
Following is a list of cold laser controlled, randomized, double-blind studies,* which have shown that Cold Laser Therapy is an effective treatment modality for a wide range of treatment indications such as:
*Achilles tendinitis: Bjordal, J.M., et al. (2006). A randomized, placebo controlled trial of low level laser therapy for activated Achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations. British Journal of Sports Medicine 40, pp. 75-80.
Acne vulgaris: Seaton, E.D., et al. (2003). Pulsed-dye laser treatment for inflammatory acne vulgaris: randomised controlled trial. The Lancet 362, pp. 1347-1352. Acute pain (Review paper): Bjordal, J.M., et al. (2006). Low-Level Laser
Therapy in Acute Pain: A Systematic Review of Possible Mechanisms of Action and Clinical Effects in Randomized Placebo-Controlled Trials. Photomedicine and Laser Surgery 24(2), pp. 158-168.
Carpal tunnel syndrome: Ekim, A., et al. (2007). Effect of low level laser therapy in rheumatoid arthritis patients with carpal tunnel syndrome. Swiss Medical Weekly 23-24, pp. 347-352.
Chronic neck pain: Chow, R.T., et al. (2006). The effect of 300 mW, 830 nm laser on chronic neck pain: A double-blind, randomized, placebo-controlled study. Pain 124(1-2), pp. 201-210.
Herpes simplex: Schindl, A., and Neumann, R. (1999). Low-Intensity Laser Therapy is an Effective Treatment for Recurrent Herpes Simplex Infection. Results from a Randomized Double-Blind Placebo-Controlled Study. Investigative Dermatology 113, pp. 221-223.
Myofascial Pain Syndrome Gur, A., et al. (2004). Efficacy of 904 nm Gallium Arsenide Low Level Laser Therapy in the Management of Chronic Myofascial Pain in the Neck: A Double-Blind and Randomize-Controlled Trial. Lasers in Surgery and Medicine 35, pp. 229-235.
Oral Mucositis: Bensadoun, R.J., et al. (1999). Low-energy He/Ne laser in the prevention of radiation-induced mucositis – A multicenter phase III randomized study in patients with head and neck cancer Support Care Cancer 7, DOI 10.1007/s005209900034.
Osteoarthritic Knee Pain (Review paper): Bjordal, J.M., et al. (2007). Short-term efficacy of physical interventions in Osteoarthritic knee pain. A systematic review and meta-analysis of randomized placebo-controlled trials. BNC – Musculoskeletal Disorders, DOI 10.1186/1471-2474-8-51.
Postmastectomy Lymphedema Carati, C.J., et al. (2003). Treatment of Postmastectomy Lymphedema with Low-Level Laser Therapy. American Cancer Society, DOI 10.1002/cncr.11641.S
Stroke: Lampl, Y., et al. (2007). Infrared Laser Therapy for Ischemic Stroke: A new Treatment Strategy. Results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1). Stroke, DOI 10.1161/STROKEAHA.106.478230.
Tendinitis and Myofascial Pain Syndrome (includes Epicondylitis, trochanteritis, etc): Lögdberg-Andersson, M., et al. (1997). Low Level Laser Therapy (LLLT) of Tendinitis and Myofascial Pains – A Randomized, Double-Blind, Controlled Study. LLLT 9, pp. 79-86.
Tinnitus: Gungor, A., et al. (2007). Effectiveness of trans meatal low power laser irradiation for chronic tinnitus. The Journal of Laryngology & Otology, DOI 10.1017/S0022215107009619