Laser Therapy Science and Clinical Studies

To date, there are now over 6000 Positive Clinical Studies and Research Papers that support Photobiomodulation Therapy (PBMT) / Cold Laser Therapy (CLT) /  Low-Level Laser Therapy (LLLT) as an effective modality for a wide range of conditions.  Over 200,000 health care providers are using cold lasers devices in their practice and over 800,000 have purchased a laser for private use. High quality therapeutic cold laser devices are effective for pain relief, the reduction of inflammation, increasing microcirculation, and promoting the body's natural healing process.

*While many of the following clinical studies have shown positive results, no medical claims are being made other than for those issues such as pain and inflammation, for a specific lasers that have been cleared for such by the FDA. 

Controlled Double Blind Studies with Photobiomodulation Therapy (PBMT) / Cold Laser Therapy (CLT) / Low Level Laser Therapy (LLLT)

Following is a list of cold laser controlled, randomized, double-blind studies,* which have shown that Cold Laser Therapy is an effective treatment modality for a wide range of treatment indications such as:

  • Acne Vulgaris
  • Achilles tendonitis
  • Ankle sprains
  • Arthritis
  • Carpal tunnel syndrome
  • Chronic back pain
  • Chronic neck pain
  • Epicondylitis
  • Herpes simplex
  • Lymphedema
  • Myofascial pain syndrome
  • Oral mucositis
  • Shoulder pain
  • Sports injuries
  • Stroke
  • Temporomandibular dysfunction
  • Tinnitus

*Achilles tendinitis: Bjordal, J.M., et al. (2006). A randomized, placebo controlled trial of low level laser therapy for activated Achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations. British Journal of Sports Medicine 40, pp. 75-80.

Acne vulgaris: Seaton, E.D., et al. (2003). Pulsed-dye laser treatment for inflammatory acne vulgaris: randomised controlled trial. The Lancet 362, pp. 1347-1352. Acute pain (Review paper): Bjordal, J.M., et al. (2006). Low-Level Laser

Therapy in Acute Pain: A Systematic Review of Possible Mechanisms of Action and Clinical Effets in Randomized Placebo-Controlled Trials. Photomedicine and Laser Surgery 24(2), pp. 158-168.

Carpal tunnel syndrome: Ekim, A., et al. (2007). Effect of low level laser therapy in rheumatoid arthritis patients with carpal tunnel syndrome. Swiss Medical Weekly 23-24, pp. 347-352.

Chronic neck pain: Chow, R.T., et al. (2006). The effect of 300 mW, 830 nm laser on chronic neck pain: A double-blind, randomized, placebo-controlled study. Pain 124(1-2), pp. 201-210.

Herpes simplex: Schindl, A., and Neumann, R. (1999). Low-Intensity Laser Therapy is an Effective Treatment for Recurrent Herpes Simplex Infection. Results from a Randomized Double-Blind Placebo-Controlled Study. Investigative Dermatology 113, pp. 221-223.

Myofascial Pain Syndrome Gur, A., et al. (2004). Efficacy of 904 nm Gallium Arsenide Low Level Laser Therapy in the Management of Chronic Myofascial Pain in the Neck: A Double-Blind and Randomize-Controlled Trial. Lasers in Surgery and Medicine 35, pp. 229-235.

Oral Mucositis: Bensadoun, R.J., et al. (1999). Low-energy He/Ne laser in the prevention of radiation-induced mucositis – A multicenter phase III randomized study in patients with head and neck cancer Support Care Cancer 7, DOI 10.1007/s005209900034.

Osteoarthritic Knee Pain (Review paper): Bjordal, J.M., et al. (2007). Short-term efficacy of physical interventions in Osteoarthritic knee pain. A systematic review and meta-analysis of randomised placebo-controlled trials. BNC – Musculoskeletal Disorders, DOI 10.1186/1471-2474-8-51.

Postmastectomy Lymphedema Carati, C.J., et al. (2003). Treatment of Postmastectomy Lymphedema with Low-Level Laser Therapy. American Cancer Society, DOI 10.1002/cncr.11641.S

Stroke: Lampl, Y., et al. (2007). Infrared Laser Therapy for Ischemic Stroke: A new Treatment Strategy. Results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1). Stroke, DOI 10.1161/STROKEAHA.106.478230.

Tendinitis and Myofascial Pain Syndrome (includes Epicondylitis, trochanteritis, etc): Lögdberg-Andersson, M., et al. (1997). Low Level Laser Therapy (LLLT) of Tendinitis and Myofascial Pains – A Randomized, Double-Blind, Controlled Study. LLLT 9, pp. 79-86.

Tinnitus: Gungor, A., et al. (2007). Effectiveness of transmeatal low power laser irradiation for chronic tinnitus. The Journal of Laryngology & Otology, DOI 10.1017/S0022215107009619

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